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Wang J, Zhu X, Li X, et al

These findings establish the gut-liver axis as a primary mediator of cadmium toxicity and a potential target for therapeutic intervention (127)

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Regarding SLC transporters, reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), organic anion transporter 3 (OAT3), and organic anion transporting polypeptide 1A2 (OATP1A2) all transport MTX as a substrate (Badagnani et al