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It is evident that the NP shape modulates the endocytosis kinetics of NPs in the efficient coarse-grained molecular dynamics (CGMD) model ( 2 O 3 ) NPs, rod-shaped Fe 2 O 3 NPs were found to cause more severe toxic effects in mouse macrophage cells (RAW 264.7) with higher levels of lactate dehydrogenase (LDH) and tumor necrosis factor- (TNF-), reactive oxygen species (ROS) generation and necrosis (Lee et al., 2014)