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First-line obesity treatments include lifestyle intervention (e.g., low-calorie diets) and behavioral modification therapies 4,5 since approved obesity medications have limited efficacy and commonly have side effects 6

36 , e00316 (2016)

Conclusion and prospects The occurrence of ferroptosis can be summarized as disruption of iron metabolic homeostasis or System X c /GSH/GPX4 pathway by various factors causing the depletion of cellular antioxidants and amplification of ROS production, ultimately leading to the accumulation of lipid peroxides and triggering ferroptosis

Brain health & neuroprotection: Emerging evidence hints that BPC 157 may benefit the brain, in very positive ways