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The product is classified as a chemical reagent/reference material authorised for use in the European Union and may only be used for scientific research

Fourteen reported subjective improvement, but there was no control group, no blinded assessment, no objective functional endpoint and no follow-up imaging endpoint [5]

It occurs naturally in human plasma, saliva, and urine, and its plasma concentration declines significantly with age, from approximately 200 ng/mL in young adults to much lower levels in older individuals