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In 1921, insulin was the first peptide to be synthesised in a laboratory, but public interest in their therapeutic use waned until 2017, when semaglutide, better known as Ozempic, was approved by the United States Food and Drug Administration

HuZChenLZhaoJZhangWJinZSunYet alLipoxin A4 ameliorates knee osteoarthritis progression in rats by antagonizing ferroptosis through activation of the ESR2/LPAR3/Nrf2 axis in synovial fibroblast-like synoviocytes