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These formulations have limited evidence supporting their superiority over standard oral tablets

Diminished BDNF concentrations within the realms of the hippocampus and prefrontal cortex result in hindered synaptogenesis, diminished neuroplasticity, and a slowdown in neurogenesis (38)

Importantly, supplementation can **increase** measurable NAD+ metabolism: in a 2018 randomized, placebo-controlled crossover trial published in Nature Communications by Martens and colleagues at the University of Colorado Boulder (24 healthy middle-aged and older adults), 1,000 mg/day of the NAD+ precursor nicotinamide riboside (500 mg, twice daily) elevated NAD+ in blood cells by roughly 60% versus placebo over 6 weeks, with no serious adverse events reported