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Drugs like cocaine, methamphetamine, bath salts (synthetic cathinones), and MDMA (ecstasy or molly) all activate the brains reward systems, triggering the release of the neurotransmitters serotonin, dopamine, and norepinephrine

Yet studies, such as this one in Nature , found that the nicotine delivery to the bloodstream from these devices varied, and was still much slower and lower than the concentrations that regular cigarettes give smokers

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Overall, smoking reduces the amount of oxygen in your blood, increases heart rate, raises blood pressure, makes blood stickier and more likely to clot, thickens the walls of the arteries so they are easier to block, and damages the blood vessels in your brain