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5.2.2 Mitochondrial dysfunction Ketamine disrupts mitochondrial function by reducing the membrane potential, increasing cytochrome c release, and promoting ROS generation, which collectively induce neuronal apoptosis ( Human studies have identified metabolic abnormalities in ketamine abusers, particularly in the prefrontal cortex, which may reflect mitochondrial dysfunction (Liao et al., 2011)

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The epithalamin-treated group also had reduced rates of coronary artery disease, hypertension, and osteoarthritis, compared to the control group participants [6]