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Regulatory hurdles: Extensive safety data requirements delay approvals, and manufacturing scalability issues, along with high production costs, limit accessibility, especially in low-income regions

Nature Communications 7:11190

Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties

We also observed an increase in the 18 kDa translocator protein TSPO, which is a mitochondrial cholesterol-binding protein and upregulated in microglia during inflammatory activation associated with neurodegeneration (Fig