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The catabolism of tyrosine involves five reactions, four of which have been shown to be associated with inborn errors in metabolism and three of these result in clinically significant disorders

Incompatible ingredients requiring separation include vitamin C (use morning versus evening rather than together), strong exfoliating acids (alternate nights rather than same routine), and retinoids (can be combined carefully but may increase irritation, alternating nights often works better)

Papapanou PN, Tonetti MS