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In accordance with results from previous studies, we demonstrated that xCT and GPX4 mRNA and protein expression, both of which are key molecules involved in ferroptosis, were significantly decreased in cultured tubular epithelial cells exposed to TGF-1 and in the kidneys of STZ mice, suggesting that these changes may contribute to the decrease in glutathione concentration and the increase in lipid peroxidation

Cao X, Yang F, Zheng J, Wang X, Huang Q

Hayes J

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