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It inhibited the proliferation of human osteosarcoma MG-63 cells and induced apoptosis in a dose-dependent manner

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Another study investigating the effects of combined treatment of MCF-7 with a fermented mistletoe preparation (VAE) and TAM reported that the combination of clinically relevant doses of VAE with TAM metabolite endoxifen did not show significant inhibition of TAM metabolism catalyzed by CYP3A4/5 and CYP2D6, indicating mistletoe ( Viscum album L.) preparations can be combined with TAM without the risk of HDI in vitro (Weissenstein et al., 2019)