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Most research suggests cumulative exposure over time is more important than precise timing

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executive dysfunction, which can include problems with planning, cognitive flexibility, abstract thinking, rule acquisition, initiating appropriate actions and inhibiting inappropriate actions, and selecting relevant sensoiy information, fluctuations in attention and slowed cognitive speed, memory (especially in recalling learned information), visuospatial difficulties e.g

Alzheimers disease profiled by fluid and imaging markers: tau PET best predicts cognitive decline