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When autophagic flux is inhibited by 3-methyladenine and chloroquine in HEI-OC1 cells, a significant increase in cell death is observed [49]

According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, weight loss medications should be offered as chronic treatment along with lifestyle modifications to patients with obesity when the potential benefits outweigh the risks

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