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Hanania E, Fu S, Roninson I, Mechetner E, Hegewisch-Becker S, Andreeff M , Berenson R, Heimfeld S, Gottesman M, Deisseroth A

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The number of nucleoli and the expression of nucleolar proteins increased when Rpl15 was overexpressed, and abnormal increases in nucleolar size and number caused by dysregulation of ribosome biogenesis have emerged as hallmarks of the majority of spontaneous cancers 42

Induced protein degradation: an emerging drug discovery paradigm