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However, the absence of known interactions may partly reflect the limited scope of formal studies on NAD+ therapy, so this lack of interactions should be interpreted with caution

Furthermore, oxidative stress can enhance the expression of matrix metalloproteinases (MMPs), enzymes that degrade the extracellular matrix and facilitate tumor invasion and metastasis [116]

With sufficient glutathione present, NAPQI is very quickly metabolized into sulfate and cysteine compounds, which are readily excreted through the kidneys.[ref] However, when it isnt neutralized, NAPQI is highly reactive and can cause oxidative stress and damage to the liver cells, hepatocytes, leading to cell death