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In a maintenance trial, nausea affected 47% of participants during escalation but fell to 14% after the same 2.4 mg dose was held. Receptor exposure stayed constant

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3 Ferroptosis in RCC 3.1 Ferroptosis signaling pathway and RCC 3.1.1 HIF-iron metabolism pathway involved in ferroptosis and RCC ccRCC is associated closely with mutations in the VHL gene that lead to the activation of HIF-1 and HIF-2 via a pseudohypoxia mechanism, resulting in the transcription of genes involved in tumor progression (76)