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Some dermatoses can be confused with DRESS, such as Stevens-Johnson syndrome, toxic epidermal necrolysis, extensive erythema multiforme, AGEP, staphylococcal scalded skin syndrome, and febrile drug exanthema.6668 The main infectious diseases that can lead to diagnostic confusion are EBV infection (infectious mononucleosis), CMV, hepatitis A, hepatitis B virus and acute HIV infection, COVID-19, Parvovirus B19, Mycoplasma pneumoniae, Zika virus, dengue, and secondary syphilis.69 The main autoimmune or autoinflammatory diseases to be considered in the differential diagnosis are systemic lupus erythematosus, adult Still's disease, Schnitzler syndrome and Kawasaki disease