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Although, endogenous melatonin production is closely related with the onset and offset of sleep, few associations have been found between melatonin production and sleep stages (95), and sleep deprivation does not abolish the melatonin rhythm

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The observation that ALLO transiently increases CREB phosphorylation and increases indicators of neurogenesis in wildtype rats (201) suggests that the acute and chronic effects may not be the same