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The follicles with smaller number of FSH receptors are unable to grow more and will gradually degenerate

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In animal and cellular models, metformin reduces cardiomyocyte hypertrophy and lactate dehydrogenase release by downregulating HIF-1 and PPAR-, implicating the HIF-1/PPAR- axis in limiting pathological growth (Liu et al., 2022)

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