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Similar content being viewed by others Introduction Type 2 diabetes mellitus (T2DM) and obesity are becoming more and more common worldwide, a phenomenon which greatly increases morbidity and mortality from conditions like cancer and heart disease, among many others [1]

Activation of the HPA axis during the training greatly increases the cortisol levels (112), which acts as a metabolic and catabolic hormone (113) by mobilizing the glucose (114), endogenous stores of amino acids (115), and fatty acids (116), enhances the availability of all fuel substrates