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In high doses and especially after prolonged use, other psychiatric symptoms may develop, such as: Depression Apathy, lethargy Memory problems Mood swings, sadness, anxiety Amotivational syndrome, lack of energy, lack of initiative Personality changes, increased introversion, quietness Altered perception of reality Cognitive impairment Paranoid ideas Psychotic symptoms Personality changes can become permanent if the user continues to smoke cannabis after the primary psychosis develops