Regenerative medicine is so powerful because many of its treatment modalities work at the cellular level
Zhu S, Wang S, Luo T
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Pathological endothelial activation is multifactorial and, in addition to glucotoxic and lipotoxic injury, can reflect the combined influence of DAMPs and PAMPs (metabolic endotoxemia), pro-inflammatory cytokines and histohormones, ROS and other mediators generated during intravascular leukocyte activation and thrombophilia, stress-associated miRNAs, modified atherogenic lipoproteins, and, in the context of frequent cardiopulmonary comorbidity, hypoxia-driven cellular stress [226,827,828,829,830,831,832,833,834,835,836,837,838,839,840,841,842,843,844,845,846,847,848,849,850,851,852,853,854,855,856,857,858,859,860,861,862,863,864,865,866,867,868,869,870,871,872,873,874,875,876,877,878,879,880,881,882,883,884,885,886,887,888,889,890,891,892,893,894,895,896,897,898,899,900,901,902,903,904,905,906,907,908,909,910,911,912,913,914,915,916,917,918,919,920,921,922,923,924,925,926,927,928,929,930,931,932,933,934,935,936,937,938,939,940,941,942,943,944,945,946,947,948,949,950,951,952,953,954,955,956,957,958,959,960,961,962,963,964,965,966,967,968,969,970,971,972,973,974,975,976,977,978,979,980,981,982,983]
