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The risk is greatest among infants who are fed formula low in biotin, people taking antiepileptic medications, infants with Leiners disease or people who are genetically predisposed to deficiency ( Untreated biotin deficiency can cause neurological symptoms, such as seizures, intellectual disability and loss of muscle coordination ( Deficiency has also been reported in animals fed high amounts of raw egg whites

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Poor ATP production may limit SAM generation even when methionine is available