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These compounds increase cell permeability and inhibit the activity of selected membrane enzymes/transport proteins, but they can also induce COX-2 expression in macrophages (87)
Simultaneous emergence of multidrug-resistant candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses
Vonoprazan Advantages Compared to Other PPIs There are some speculative arguments in favor of the application of vonoprazan instead of other PPIs as antisecretory drugs: (1) it is more potent in the inhibition of acid secretion, (2) it has a fast onset of action, (3) less antisecretory variation is reported, as well as (4) greater safety, and (5) better tolerability
Further elucidation of these mechanisms may enhance our understanding of pyroptosis in DOR and aid in the development of natural product-based therapies targeting pyroptosis-related factors
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