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However, systemic copper loading remains a theoretical concern requiring careful dose optimization and copper status monitoring, particularly with chronic administration protocols

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Although almost from the time of its inception, AFM was successfully used in structural analysis of ordered proteins, utilization of this tool for structural and dynamics characterization of IDPs was originally limited due to the fact that IDPs do not have stable 3D structure but dynamically sample a multitude of conformational states

Neither route is backed by human clinical trial data, so any route advantage is extrapolated from animal pharmacology