If B-complex vitamins are recommended, patients should be aware that high doses of vitamin B6 (exceeding 100 mg daily) can cause peripheral neuropathy
This article evaluates what the research actually shows
The risks fall into three buckets Common, mild, self-limiting Bruising or soreness at the catheter site Cool sensation along the arm during the drip Warm flush or metallic taste, especially with magnesium or B-complex Mild lightheadedness if the drip runs too fast Uncommon Phlebitis, or vein irritation, especially with stronger or more concentrated formulas Infiltration (fluid leaking under the skin if the catheter shifts) Allergic reactions to specific ingredients, particularly thiamine and B-complex Rare but serious Infection at the IV site Fluid overload in patients with heart, kidney, or liver disease Electrolyte disturbances, especially with high-dose magnesium, potassium, or calcium Red blood cell problems in people with G6PD deficiency, a genetic enzyme issue
Whether this advantage is enough to make direct NAD+ delivery superior to precursors remains debated, but the technology is promising