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If pharmacotherapy is not available, e-cigarettes have been shown to be at least as effective as nicotine replacement therapy in helping people stop, roughly doubling abstinence rates

However, pipe tobacco is designed for puffing rather than inhaling, so it burns differently, may be harsher on the throat, and delivers nicotine in a distinct way compared to cigarette tobacco

Upon further experimentation, Mineur and his team found that a particular subunit (the 4 subunit) in nicotinic acetylcholine receptors is directly involved in producing anorexic effects

I do want to add some visual "drunk" effect type thing for some plants