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According to the Substance Abuse and Mental Health Services Administration (SAMHSA), in 2020, nearly 50% of individuals who sought treatment for substance use disorders reported polysubstance abuse

An eight-fold increase (from 1.5 percent to 11.7 percent) in the use of e-cigarettes among high school students between 2011 and 2017 More teenagers use e-cigarettes today than smoke regular cigarettes The most popular brand is JUUL, an e-cigarette shared like a USB flash drive so it is easily hidden from parents and teachers

Contributing to this report were Allen Breed in Lexington and Ninety Six, South Carolina

No differences have been seen between the genders (Table S2)