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GABA Levels and Receptor Interaction: Limited and Conflicting Evidence Although NAC indirectly influences GABAergic neurotransmission through its modulation of glutamatergic tone and astrocytic function, direct effects on GABA levels remain inconclusive

In the FAS population, the median GSH concentration appeared artificially higher in the placebo (459 mol/L) than in the NAC (402 mol/L) group, due to imputation method for missing values (15%-NAC and 5%-Placebo) (Fig

Aust New Z J Obstetrics Gynaecology

In these roles, NAC may be a useful monotherapy or augmentation strategy for psychiatric disorders related to oxidative stress (e.g., schizophrenia and bipolar disorder) and/or psychiatric syndromes characterized by impulsive/compulsive symptoms (e.g., trichotillomania, nail biting, pathological hair pulling, substance misuse, and gambling)