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The experimental protocol was approved by IACUC of the University of Kentucky based on the NIH guidelines

As I mentioned above, excessive alcohol consumption activates cytochrome P450 2E1 (CYP2E1) - the enzyme used in the MEOS process

Enhanced oxidative stress is known to enhance COPD-related inflammation in ex-smokers which in turn may activate proinflammatory transcription factors involving nuclear factor kappa B (NF-B), DNA damage, cellular senescence, and formation of autoantibody

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