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According to the CDC, the inhaled aerosol can contain: Nicotine Ultrafine particles that can be inhaled deep into the lungs Flavoring such as diacetyl, a chemical linked to a serious lung disease Volatile organic compounds Cancer-causing chemicals Heavy metals such as nickel, tin, and lead 1 Aside from this, they still deliver highly addictive nicotine that can harm the parts of the adolescent brain that control attention, learning, mood, and impulse control