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As discovered more recently by Zhangs group, NRF2 can also be negatively regulated through the E3 ubiquitin-protein ligase synoviolin (HRD1), recently associated with the ER stress produced by misfolded protein accumulation

J Ovarian Res 18 , 115 (2025)

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Also, melanogenic switching was found to be related to tyrosinase activity levels, where high tyrosinase activity produced an excess of dopaquinone resulting in the inactivation of GR and other enzymes essential for pheomelanogenesis [99]