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Markers of nitrosative stress are prevalent in tissues from both Parkinson's and Alzheimer's disease patients, indicating a significant role for nitric oxide in disease pathogenesis [59, 60]

Assuming a sequential reaction, where the enzyme, GPX, must bind to both substrates, ROS and GSH, for the reaction producing GSSG to occur and letting ROS and GSH to be the leading and following substrates, respectively, is the the reaction rate for GSSG

But the same property that makes it useful in culture is what makes any extrapolation to human physiology fraught: broad, persistent activation of a receptor that regulates growth, metabolism, and cell survival across virtually every tissue is a fundamentally different proposition from a self-limiting local pulse

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