glutathione steven johnson syndrome Updates in the pathogenesis of SJS/TEN Glutathione as a skin whitening

Extracellular glutathione is a source of cysteine for cells that express gamma-glutamyl transpeptidase

Research has identified several key molecular pathways through which this peptide exerts its cytoprotective and regenerative functions

Glutamate accumulation to micromolar levels [375] results in GluN2B-mediated NMDA receptor overactivation, Ca 2+ overload, and subsequent tau hyperphosphorylation and dendritic spine collapse [376], linking excitotoxicity to amyloidogenesis [28]

Cephalalgia 37(13):12721284 Resta F et al (2016) Kynurenic acid and zaprinast induce analgesia by modulating HCN channels through GPR35 activation