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149 Furthermore, certain drugs like amitriptyline, commonly prescribed for depression, have been found to bind reversibly to the G-sites of GSTP1 and GSTA1, leading to a significant reduction in their activity
A fundamental investigation that infected African green monkey kidney (Vero) cells with patient-derived SARS-CoV2 discovered that the mRNA levels of GPX4 were considerably downregulated, suggesting a connection between ferroptosis and SARS-CoV-2 [78]
The oxidant-antioxidant imbalance in the erythrocytes of sALS patients was confirmed, more recently, in another study where GSH reductase and reduced GSH levels were also found to be significantly lower at 24 months from the onset of ALS, in patients who died shortly after [104]
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