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Drug and Nutrition Interactions: Not Just Food for Thought

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

The REDUCE-IT trial (N=8,179), which used 4 g/day of icosapentaenoic acid ethyl ester (Vascepa), reported a higher rate of atrial fibrillation and total bleeding in the omega-3 arm, but that study used a mineral oil placebo now believed to have inflated comparative risk, and the absolute bleeding excess was small [12]

This is a concept called bioavailabilitythe proportion of a substance that enters the circulation when introduced into the body and so is able to have an active effect