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These interventions may include yoga, tai chi, qigong, meditation, mindfulness, breath regulation techniques, and the relaxation response.30,31 One hypothesis is that mind-body interventions reverse expression of genes involved in inflammatory processes activated by stress.32 Physical activity has been shown to exert multiple physiological benefits in major depressive disorder, including increasing BDNF.33 Whether its walking, swimming, bicycling, dancing, or some other enjoyable activity, an exercise prescription is a vital component of a mood-boosting care plan

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However, some individuals may experience mild side effects such as nausea, vomiting, or digestive upset

All animals were housed at standard temperature (~22C) and humidity-controlled conditions under a 14L:10D photoperiod and provided ad libitum access to water and a low-fat-purified diet upon arrival (10% calories from fat D12450H Research Diets Inc)