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Thiol (-SH) groups of membrane proteins, the lens epithelial cells, which are significant for regulation of ion transport, are very susceptible to oxidative attack, especially when the concentration if intracellular GSH is reduced

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These include: Mild nausea or digestive discomfort (more common with oral forms) Dizziness or lightheadedness Injection site irritation, redness, or swelling Possible changes in appetite These side effects typically go away on their own and do not pose long-term risks

Based on the above discussion, we suggest that the major candidates to perform this function are (1) DHARs, (2) GSTs, and (3) GRX-PRXII