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I wouldnt usually use something new on my skin twice a day, but I am currently not using any other actives so hoped it wouldnt be a problem

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, such as through MT1 or MT2 or other receptors/regulatory proteins, changes induced by melatonin or its metabolites in mitochondrial activity that affect the activity of ROR, and indirectly affecting the activity of the nuclear receptor, REV-ERB, which also interacts with the RORE, thus influencing the expression of the same target genes as the ROR [25]