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Glucagon receptor activation primarily increases hepatic energy expenditure, promotes liver fat oxidation, and stimulates thermogenesis

Glutathione reductase regenerates reduced GSH from its oxidized form (GSSG) using NADPH, predominantly sourced from the pentose phosphate pathway

[DOI] [PubMed] [Google Scholar] 19.Carpene C, Rebourcet MC, Guichard C, Lafontan M, Lavau M

Meakin, P.J., et al., Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance