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A decline in ACE2 function in aged individuals, coupled with the age-associated deterioration in mitochondrial functions results in chronic metabolic disorders like diabetes or cancer, and predisposes the host for increased susceptibility to infection, vulnerability to health complications, and intensifies the risk of mortality 163

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Furthermore, this guidance focused on the toxicity testing methods of nanomedicines on multiple systems including immunogenicity and immunotoxicity, neurotoxicity, genotoxicity, carcinogenicity, and reproductive toxicity