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Towards the end of the secretory phase, prior to the onset of menses, the endometrium has differentiated into three zones: the deepest layer remains the unchanged basalis layer, the middle layer is the stratum spongiosum, or loose edematous stroma containing tightly coiled spiral vessels and dilated glands, and the most superficial layer is the more stromally dense stratum compactum (Owusu-Akyaw et al., 2019)