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Together they reduce binding affinity to the six IGF binding proteins (IGFBP-1 through IGFBP-6) by approximately one to two orders of magnitude, while preserving full agonist activity at the type 1 IGF receptor

In the future, rather than look for additional global markers of astrogliosis, it will likely be more useful to look for molecules upregulated by astrocytes in specific contexts and that are associated with specific functions or effects of astrogliosis

Specifically, the proportion of Firmicutes is markedly reduced, the Bacteroidetes-to-Firmicutes ratio is decreased, and the abundance of Acidobacteria is increased (Soltysova et al., 2022)