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However, insulin stimulated a more rapid receptor internalization of IR and IR/IGF1R with a 50% reduction of the surface-labelled IR and IR/IGF1R receptors by 30 min, whereas IGF-1 led to internalization of only 20% the surface IGF1R and IGF1R/IR by 30 min (Supplementary Fig

In addition, the HA/ZIF-8@Gem/D-1-MT nanoparticles obtained by loading gemcitabine and D-1-methyltryptophan into ZIF-8 and then modifying with HA, can also reactivate anti-tumor immunity by inhibiting indoleamine 2,3-dioxygenase and reducing the infiltration of M-MDSCs and G-MDSCs (123)