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10.3969/j.issn.1671-6450.2004.04.001 142 YouJ

In acquired epilepsy syndromes, multiple reports have consistently shown that seizures induce oxidative damage following excessive ROS generation in the brain, exacerbating network excitability [59,60,71]

The enzyme that acts as the rate-limiting step in cholesterol biosynthesis is 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase [74,75,76,77,78,79,80]