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Taking these medications long-term is associated with an increased risk of serious side effects such as heart attack, stroke, heart failure, gastrointestinal bleeding, ulceration, and perforation, kidney injury, potential liver strain, and serotonin syndrome

A significant elevation in lipid peroxides (LPO) level, glutathione-S-transferase activity and total antioxidant capacity (TAC) and a significant reduction in superoxide dismutase activity were found in MSG group

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MMWR Surveillance Summaries 2012