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In a clinical trial of bupropion immediate-release in MDD subjects with stable congestive heart failure (CHF) (N=36), bupropion was associated with an exacerbation of pre-existing hypertension in 2 subjects, leading to discontinuation of bupropion treatment

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Treatment Implications The advantage of broadening our understanding about the underlying neurobiology of this comorbidity is that it may lead to more novel, targeted treatments to be developed