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Products without antioxidant stabilizers (such as vitamin E, ferulic acid at pH-compatible concentrations) or without inert gas blanketing during manufacture degrade before reaching the consumer

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The FDA evaluation found insufficient evidence to establish effectiveness for the nominated use and highlighted gaps in physicochemical characterisation, immunogenicity and safety information

A 2001 Journal of Biological Chemistry paper characterised the ternary complex among profilin, Thymosin -4, and actin (PMID 11579089)