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Depicts MTHFR variant activity For example, an individual who is heterozygous at both C677T (C/T) and A1298C (A/C), known as a compound heterozygote, is expected to exhibit a 55% decrease in MTHFR enzymatic activity (35% activity due to the presence of one T allele at C677T and 20% activity due to the presence of one C allele at A1298C = 55%)

Cellular energy dysfunction may contribute to depression through various pathways, leading to neurotoxicity and impaired neuroplasticity [4, 56]

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Function as enzymatic cofactors in the metabolic pathways that use methionine, inositol, and choline